Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens

Danielle A. Garsin, Jacinto M. Villanueva, Jakob Begun, Dennis H. Kim, Costi D. Sifri, Stephen B. Calderwood, Gary Ruvkun, Frederick M. Ausubel

Department of Genetics, Massachusetts General Hospital, Boston, MA 02114, USA.
Department of Microbiology and Molecular Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.

Our laboratories have studied the mechanisms of aging and immune function in Caenorhabditis elegans. Herein we show that the mechanisms that govern these two processes may be interrelated.