Name: Laurent Seroude Date of birth: September 13th, 1965 at Castres (81), FRANCE Citizenship: French Familly situation: Married, 2 children Address: 468 Montreal St, Kingston, Ontario K7K 3H8, Canada Home tel: 613.548.4192 Lab tel: 613.533.6769 Lab fax: 613.533.6617 Email: seroudel@biology.queensu.ca Email: lseroude@mac.com University Paul Sabatier, Toulouse, France - Ph.D of Molecular Genetics, "Determinants of functionnal specificity of homeotic protein proboscipedia", conferred with Honours September 25 1995. - Diplôme d'Etudes Approfondies (DEA) of Microbiology and Biotechnology, option Molecular Biology with Honours, conferred September 1991. - Maîtrise of Cellular Biology (MSc), option Genetics; with Honours conferred June 1990. - Licence of Biochemistry; with Honors conferred June 1990 - Licence of Cellular Biology; with Honors conferred June 1989 - DEUG B (BSc); with Honors conferred June 1988 Assistant Professor of Biology Address: Department of Biology, Biosciences Complex, Queen's University, Kingston, ON K7L 3N6, Canada Tel: 613.533.6769 Fax: 613.533.6617 Email: seroudel@biology.queensu.ca - MRT (Ministère de la Recherche et de la Technologie) 1991-1994 - ARC (Association pour la Recherche contre le Cancer) 1994-1995 - Fight for sight 1996-1997 - Caltech Cline Fund 2001-2002 "Identification of the Methuselah G Protein Coupled Receptor Ligand" - Queen's young investigator research grant 2001-2002 "Molecular Genetics of Aging in Drosophila" - Queen's Advisory Research Committee (ARC) 2002-2003 "Computing Equipment for the Identification of DNA Regulatory Sequences Responsible for Age-Dependent Gene Regulation" - Canada Foundation for Innovation (CFI) New Opportunities 2002-2007 "Molecular Genetics of Aging in Drosophila" - Ontario Innovation Trust (OIT) 2002-2007 "Molecular Genetics of Aging in Drosophila" - Natural Sciences and Engineering Research Council of Canada (NSERC) 2002-2006 "Dissection of Age-Dependent Gene Expression" February 1992: 33rd Drosophila Research Conference, Philadelphia, USA Benassayag C., Seroude L., Cribbs D. (Poster) "Structure/function relationships of the homeotic proboscipedia protein" September 1993: 8éme Journées Françaises de Génétique et de Biologie moléculaire de la Drosophile, Vichy, France Seroude L., Benassayag C., Boube M., Cribbs D. (Oral) "Functional analysis of proboscipedia protein isoforms" September 1993: 13th European Drosophila Research conference, Aghia Pelaghia, Crete, Greece Cribbs, D.L., Benassayag, C., Seroude, L., Boube, M. (Oral) "Levels of the homeotic proboscipedia gene product play an important role in the acquisition of segmental and cell identity" September 1993: 13th European Drosophila Research conference, Aghia Pelaghia, Crete, Greece Seroude, L., Benassayag, C., Boube, M., Cribbs, D.L. (Poster) "Structure/function relationships of the homeotic proboscipedia protein" April 1994: 35th Annual Drosophila Research Conference, Chicago, USA Cribbs, D., Benassayag, C., Boube, M., Seroude, L. (Oral) "Homeotic function of proboscipedia is modified by the Ras1 signaling pathway" September 1994: 9éme Journées Françaises de Génétique et de Biologie moléculaire de la Drosophile, Vichy, France Seroude L., Benassayag C., Boube M., Cribbs D. (Oral) "Determinants of functional specificity of homeotic protein proboscipedia" November 1995: Southern California Drosophila Research Conference, University of California , Irvine, USA Seroude L., Benassayag C., Boube M., Cribbs D. (Oral) "Determinants of functional specificity of homeotic protein proboscipedia" April 1996: 37th Annual Drosophila Research Conference, San Diego, USA Boube, M., Benassayag, C., Seroude, L., Blondeau, F., Cribbs, D. (Oral) "Identification and characterization of genes modifying the action of the homeotic gene proboscipedia" Sept 1997: Neurobiology of Drosophila, Cold Spring Harbor, USA Seroude, L., Buchanan, R., Kretzchmar, D., Kim, C., Benzer, S. (Poster) "Functional analysis of the drop-dead gene expression pattern" March 1999: 40th Annual Drosophila Research Conference, Bellevue, USA Seroude, L., Benzer, S. (Poster) "How to murder a fly (A genetic scream for age-dependent enhancers)" August 1999: World Federation of Neurology (WFN), 18th International Meeting, The Hague, The Netherlands Kazemi-Esfarjani, P., Seroude, L., and Benzer, B. (Poster) "Genetic modifiers of polyglutamine toxicity in Drosophila: a model for HuntingtonŐs disease and other polyglutamine disorders" January 2000: Gordon Research Conference on Biology of Aging, Ventura, USA Seroude, L., Lan, L., Benzer, S. (Poster) "Identification and molecular characterization of aging biomarkers" September 2000: 8th European Symposium on Drosophila Neurobiology Neurofly 2000, Alicante, Spain Seroude, L., Benzer, S. (Oral) "Genetic dissection of the aging process with GAL4 biomarkers" September 2000: 15éme Journées Francophones de la Drosophile, Cannes, France Seroude, L., Benzer, S. (Oral) "Genetics of aging in Drosophila" March 2001: 42th Annual Drosophila Research Conference, Washington, USA Song, W., Ranjan, R., Bronk, P., Nie, Z., Dawson-Scully, K., Lin, Y.J., Seroude, L., Atwood, H.L., Benzer, S., Zinsmaier, K.E. (Poster) "Methuselah, a putative G protein-coupled receptor, regulates excitatory neurotransmitter exocytosis at the larval neuromuscular junction of Drosophila" March 2001: 42th Annual Drosophila Research Conference, Washington, USA Brummel, T., Seroude, L., Lin, Y.J., Benzer, S. (Poster) "Aging genes in Drosophila" University Paul Sabatier, Toulouse, France - Teaching assistant in Genetics (1991) California Institute of Technology, Pasadena, California, USA - Mentor SURF (Summer Undergraduate Research Fellowships) student (Lily Lan)(July-Sept 1999) - Mentor MURF (Minority Undergraduate Research Fellowships) student (Annemarie Selaya(July-Sept 2000) - Mentor SURF (Summer Undergraduate Research Fellowships) student (Yingbing Wang)(July-Sept 2001) - Mentor MURF (Minority Undergraduate Research Fellowships) student (Annemarie Selaya)(July-Sept 2001) Queen's University, Kingston, Ontario, Canada - Bio596 Honor thesis student (Michel Cameron)(Sept 2001-Aug 2002) - Studies of Saccharose Phosphate Synthase in Sunflower, in the laboratory of G. Cavaille, University P. Sabatier, Toulouse, France (Summer Student)(1989) - Genetics of Cefotaxim resistance in Streptococcus pneumoniae, in the laboratory of Michel Sicard, CNRS, Toulouse, France and in the laboratory of Regine Hakenbeck, Max Planck Institut für Molekulare Genetik, Berlin, Germany (Master Student)(1989-1990) - Transposition of bacterial insertion sequence IS911, in the laboratory of Michael Chandler, CNRS, Toulouse, France (DEA Student)(1991) - Genomic structure of the Drosophila poly(A) binding protein, in the laboratory of Alain Vincent, CNRS, Toulouse, France (DEA Student)(1991) - Determinants of functional specificity of homeotic protein proboscipedia, in the laboratory of David Cribbs, CNRS, Toulouse, France (PhD Student)(1991-1995) - Molecular genetics of aging in Drosophila melanogaster, in the laboratory of Seymour Benzer, California Institute of Technology, Pasadena, USA (Post-Doc)(1995-2001) Seroude L., S. Hespert, L. Selakovitch-Chenu, A.M. Gasc, J. Lefrançois and M. Sicard (1993) Res. Microbiol., 144, 398-394 "Genetic studies of cefotaxime resistance in Streptococcus pneumoniae : relationship to transformation deficiency." Selakovitch-Chenu L., L. Seroude, S. Hespert, A.M. Gasc and A.M. Sicard (1993) in : Balla E., Berensi G (eds) Genetic transformation. DNA transfer and gene expression in micro-organisms. "Genetic studies of cefotaxime resistance in Streptococcus pneumoniae : the role of penicillin-binding protein 3." Selakovitch-Chenu L., L. Seroude and A.M. Sicard (1993) Mol. Gen. Genet., 239, 77-80 "The role of penicillin-binding protein 3 (PBP 3) in cefotaxime resistance in Streptococcus pneumoniae." Polard P., L. Seroude, O. Fayet, M.-F. Prère and M. Chandler (1994) J. Bact., 176, 4, 1192-1196 "One-ended insertion of IS911" Seroude L. and D.L. Cribbs (1994) Nucleic Acids Res., 22, 20, 4356-4357 "Differential effects of detergents on enzyme and DNA-binding activities of a glutathione S-transferase-homeodomain fusion protein" Boube M., C. Benassayag, L. Seroude and D.L. Cribbs (1997) Genetics, 146, 2, 619-628 "Ras1-mediated modulation of Drosophila homeotic function in cell and segment identity" C. Benassayag, M. Boube, L. Seroude and D.L. Cribbs (1997) Genetics, 146, 3, 939-949 "Point mutations identify sequences within and outside the homeodomain required for proboscipedia homeotic function in Drosophila" C. Benassayag*, L. Seroude*, M. Boube, M. Erard and D.L. Cribbs (1997) Mechanisms of Development, 63, 2, 187-198 (*: co-authors) "A homeodomain point mutation of the Drosophila proboscipedia protein provokes eye loss independently of homeotic function" Boube M., L. Seroude and D.L. Cribbs (1998) Int. J. Dev. Biol., 42, 3, 431-436 "Homeotic proboscipedia cell identity functions respond to cell signalling pathways along the proximo-distal axis" Lin Y., L. Seroude and S. Benzer (1998) Science, 282, 943-946 "Extended lifespan and stress resistance in the Drosophila mutant methuselah" Abstract Full text L. Seroude (2002) The ScientificWorld, 2, 618-631 "Differential gene expression and aging" Abstract Full text L. Seroude (2002) Genesis, 34, 34-38 "GAL4 drivers expression in the whole adult fly"Full text W. Song, R. Ranjan, K. Dawson-Scully, P. Bronk, L. Marin, L. Seroude, Y. Lin, Z. Nie, H.L. Atwood, S. Benzer and K.E. Zinsmaier (2002) Neuron, 36, 105-119 "Presynaptic regulation of neurotransmission in Drosophila by the G protein-coupled receptor Methuselah"Abstract Full text L. Seroude, T. Brummel, P. Kapahi and S. Benzer (2002) Aging Cell, 1, 47-56 "Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster "Abstract Full text R. Buchanan*, C. Kim*, D. Kretzschmar*, E.M. Schwarz*, L. Seroude* and S. Benzer (2002) In prep (*: co-authors) "drop dead encodes a pre-Golgi protein, with NRF-6 and O-acyltransferase homology, required to form resilin-like structures during the pupal development of Drosophila melanogaster"